small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor; not a peptide

5-Amino-1MQ

aka 5-amino-1-methylquinolinium · 5A1MQ · 5A-1MQ · 5MQ

Evidence grade
Grade D: Preclinical only
for fat loss and metabolism
User score everyone · n = 22
US FDA Not approved checked 2026-11-13
WADA 2026 Likely prohibited (S0) by class rule · checked 2026-11-13
EU No data · checked 2026-11-13

User reports

approximate — combined from two independent Reddit reads

Men 45–60

0 men aged 45–60

No reports in this group yet.

All men

0 men

No reports in this group yet.

Everyone

22 people

  • Positive: 10 of 22 (45%)
  • Mixed: 3 of 22 (14%)
  • Negative: 3 of 22 (14%)
  • Unclear: 6 of 22 (27%)
Benefits reported of 22
Benefits reported (n = 22)
ItemReports
Energy8 of 22 (36%)
Fat loss8 of 22 (36%)
Endurance2 of 22 (9%)
Focus / cognition2 of 22 (9%)
Less appetite2 of 22 (9%)
Strength2 of 22 (9%)
Blood sugar1 of 22 (5%)
Muscle1 of 22 (5%)
Side effects reported of 22
Side effects reported (n = 22)
ItemReports
GI upset3 of 22 (14%)
Fatigue2 of 22 (9%)
Anxiety1 of 22 (5%)
Heart rate up1 of 22 (5%)
Insomnia1 of 22 (5%)
Low blood sugar1 of 22 (5%)
Nausea1 of 22 (5%)
Other1 of 22 (5%)
Why people stopped of 22
Why people stopped (n = 22)
ItemReports
Side effects2 of 22 (9%)

Stopped 2 of 22 (9%) Used with other compounds 6 of 22 (27%)

User reports are anecdata, not evidence: self-selected, unverified, often combined with other compounds.

In their words

  • “I loved the fat loss and the energy, but it gave me some bad gut cramping.”

  • “it just gave me few bit of energy but nothing to what its supposed to do for fat burning”

  • “I feel great and energized with great cognitive benefits.”

  • “I started a cycle 3 weeks ago. 150mg a day. dropped 6 pounds with no change in diet. Definite disruption of sleep patterns.”

  • “Geez, my fasting blood sugar came dangerously low at 52 mg/dl. Glad I didn't pass out.”

  • “I get HORRIBLE gastritis from 5amino. Both oral and injectable.”

Read summaries and method notes

Read 1. No age-qualified male 45–60 self-reports were identifiable in the readable threads, and none of the counted reporters explicitly self-identified as male, so both male blocks remain empty. Across five distinct first-person reporters, experiences ranged from energy/clarity and modest fat-loss observations to no meaningful fat-loss effect; one reporter stopped after a reproducible adverse reaction that they suspected reflected a mislabeled or poor-quality product. The clearest adverse reports were gut cramping, a fluttery/amped feeling, and the unusual urinary/pelvic symptoms in the product-quality case. Onset for subjective energy could be immediate, whereas body-composition effects, where claimed, were slower; stacking with Reta/NAD or other compounds made attribution difficult. The sample is far below the requested target because several seed threads were question-only, inaccessible, or contained no qualifying first-person report.

Read 2. No man aged 45–60 (an "old" r/BodyHackGuide commenter was excluded). Of 22 self-reporters across 20 threads, 10 positive, 3 mixed, 3 negative, 6 unclear; fat loss (especially midsection) and clean energy led the benefits. Side effects were GI upset including severe gastritis, fatigue, and one case of severe low blood sugar (52 mg/dL) when stacked with tirzepatide. Cycles ran 2–6 weeks; users are confused between microgram SubQ and milligram oral/injectable dosing.

Note 1. Very small sample. Product identity and quality were explicit concerns in one adverse report. Several users stacked 5-Amino-1MQ, making causal attribution weak.

Note 2. Six r/BodyHackGuide threads were excluded. Dosing reports split between mcg-level SubQ vials and 50-150 mg oral/injectable protocols.

Each read counted people independently. Overlap between the two reads is estimated from shared threads and removed; counts are approximate. How we count.

Summary

5-Amino-1MQ is a small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor, not a peptide. Cell and mouse experiments report altered NAD+ and lipid metabolism; sustained NAD+ increases, beneficial sirtuin activation and fat loss in treated people have not been demonstrated. Human administration trials were not found. Foundational study

Safety

  • Human adverse-event rates, contraindications and interactions not found
  • Human pharmacokinetics and oral bioavailability not found
  • Rodent efficacy and short-term tolerability do not establish human safety
  • Long-term effects of systemic NNMT inhibition remain unestablished in humans

From labels, regulators and trials. No signal in small studies ≠ safe.

Evidence D fat loss and metabolism

D stands. Mouse and cell data only; no human trial found.

Human trials · 0

No human trials found for the marketed use.

Dose ranges

Reported ranges from labels and studies, with context. Not a recommendation.

No data.

Editorial ratings EDITORIAL

Editors’ judgement, 0–5. Opinion, not data; separate from grade and user score.

  • Safety 3 out of 5
  • Sleep 2 out of 5
  • Recovery not rated —
  • Cognitive not rated —

Sources

  1. fda.gov/media/94155/download
  2. wada-ama.org/sites/default/files/2025-09/2026list_en_final_clean_september_2025.pdf
  3. pmc.ncbi.nlm.nih.gov/articles/PMC5826726/
  4. pubmed.ncbi.nlm.nih.gov/29155147/
  5. pubmed.ncbi.nlm.nih.gov/35013352/
  6. pubmed.ncbi.nlm.nih.gov/39161060/
  7. clinicaltrials.gov/search?term=5-amino-1MQ
  8. accessdata.fda.gov/scripts/cder/daf/index.cfm
  9. fda.gov/drugs/human-drug-compounding/bulk-drug-substances-used-compounding-under-section-5
  10. fda.gov/advisory-committees/advisory-committee-calendar/july-23-24-2026-meeting-pharmacy-c
  11. hhs.gov/sites/default/files/hhs-503a-peptide-enforcement-discretion-policy-appendix-b.pdf
  12. ema.europa.eu/en/medicines

Reddit threads read · 20

6 further sources on commercial or non-primary hosts not listed.

Research checked 2026-11-13.