small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor; not a peptide
5-Amino-1MQ
aka 5-amino-1-methylquinolinium · 5A1MQ · 5A-1MQ · 5MQ
User reports
approximate — combined from two independent Reddit reads
Men 45–60
0 men aged 45–60
No reports in this group yet.
All men
0 men
No reports in this group yet.
Everyone
22 people
- Positive: 10 of 22 (45%)
- Mixed: 3 of 22 (14%)
- Negative: 3 of 22 (14%)
- Unclear: 6 of 22 (27%)
| Item | Reports |
|---|---|
| Energy | 8 of 22 (36%) |
| Fat loss | 8 of 22 (36%) |
| Endurance | 2 of 22 (9%) |
| Focus / cognition | 2 of 22 (9%) |
| Less appetite | 2 of 22 (9%) |
| Strength | 2 of 22 (9%) |
| Blood sugar | 1 of 22 (5%) |
| Muscle | 1 of 22 (5%) |
| Item | Reports |
|---|---|
| GI upset | 3 of 22 (14%) |
| Fatigue | 2 of 22 (9%) |
| Anxiety | 1 of 22 (5%) |
| Heart rate up | 1 of 22 (5%) |
| Insomnia | 1 of 22 (5%) |
| Low blood sugar | 1 of 22 (5%) |
| Nausea | 1 of 22 (5%) |
| Other | 1 of 22 (5%) |
| Item | Reports |
|---|---|
| Side effects | 2 of 22 (9%) |
User reports are anecdata, not evidence: self-selected, unverified, often combined with other compounds.
In their words
“I loved the fat loss and the energy, but it gave me some bad gut cramping.”
“it just gave me few bit of energy but nothing to what its supposed to do for fat burning”
“I feel great and energized with great cognitive benefits.”
“I started a cycle 3 weeks ago. 150mg a day. dropped 6 pounds with no change in diet. Definite disruption of sleep patterns.”
“Geez, my fasting blood sugar came dangerously low at 52 mg/dl. Glad I didn't pass out.”
“I get HORRIBLE gastritis from 5amino. Both oral and injectable.”
Read summaries and method notes
Read 1. No age-qualified male 45–60 self-reports were identifiable in the readable threads, and none of the counted reporters explicitly self-identified as male, so both male blocks remain empty. Across five distinct first-person reporters, experiences ranged from energy/clarity and modest fat-loss observations to no meaningful fat-loss effect; one reporter stopped after a reproducible adverse reaction that they suspected reflected a mislabeled or poor-quality product. The clearest adverse reports were gut cramping, a fluttery/amped feeling, and the unusual urinary/pelvic symptoms in the product-quality case. Onset for subjective energy could be immediate, whereas body-composition effects, where claimed, were slower; stacking with Reta/NAD or other compounds made attribution difficult. The sample is far below the requested target because several seed threads were question-only, inaccessible, or contained no qualifying first-person report.
Read 2. No man aged 45–60 (an "old" r/BodyHackGuide commenter was excluded). Of 22 self-reporters across 20 threads, 10 positive, 3 mixed, 3 negative, 6 unclear; fat loss (especially midsection) and clean energy led the benefits. Side effects were GI upset including severe gastritis, fatigue, and one case of severe low blood sugar (52 mg/dL) when stacked with tirzepatide. Cycles ran 2–6 weeks; users are confused between microgram SubQ and milligram oral/injectable dosing.
Note 1. Very small sample. Product identity and quality were explicit concerns in one adverse report. Several users stacked 5-Amino-1MQ, making causal attribution weak.
Note 2. Six r/BodyHackGuide threads were excluded. Dosing reports split between mcg-level SubQ vials and 50-150 mg oral/injectable protocols.
Each read counted people independently. Overlap between the two reads is estimated from shared threads and removed; counts are approximate. How we count.
Summary
5-Amino-1MQ is a small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor, not a peptide. Cell and mouse experiments report altered NAD+ and lipid metabolism; sustained NAD+ increases, beneficial sirtuin activation and fat loss in treated people have not been demonstrated. Human administration trials were not found. Foundational study
Safety
- Human adverse-event rates, contraindications and interactions not found
- Human pharmacokinetics and oral bioavailability not found
- Rodent efficacy and short-term tolerability do not establish human safety
- Long-term effects of systemic NNMT inhibition remain unestablished in humans
From labels, regulators and trials. No signal in small studies ≠ safe.
Legal status
US FDANot approved
Approval not found; not on published 503A nomination categories or final bulks list. No approved product was found; the May 14 2026 category document and current 21 CFR 216.23 do not list 5-Amino-1MQ. It was not on the July 23–24 2026 PCAC agenda. Absence from Category 2 is not authorization. Source
checked 2026-11-13WADA 2026Likely prohibited (S0)
Not named; S0 prohibition applies to unapproved pharmacological substances (interpretation of the class rule). Source
checked 2026-11-13EU
No data
checked 2026-11-13Evidence D fat loss and metabolism
D stands. Mouse and cell data only; no human trial found.
Human trials · 0
No human trials found for the marketed use.
Dose ranges
Reported ranges from labels and studies, with context. Not a recommendation.
No data.
Editorial ratings EDITORIAL
Editors’ judgement, 0–5. Opinion, not data; separate from grade and user score.
Sources
- fda.gov/media/94155/download
- wada-ama.org/sites/default/files/2025-09/2026list_en_final_clean_september_2025.pdf
- pmc.ncbi.nlm.nih.gov/articles/PMC5826726/
- pubmed.ncbi.nlm.nih.gov/29155147/
- pubmed.ncbi.nlm.nih.gov/35013352/
- pubmed.ncbi.nlm.nih.gov/39161060/
- clinicaltrials.gov/search?term=5-amino-1MQ
- accessdata.fda.gov/scripts/cder/daf/index.cfm
- fda.gov/drugs/human-drug-compounding/bulk-drug-substances-used-compounding-under-section-5
- fda.gov/advisory-committees/advisory-committee-calendar/july-23-24-2026-meeting-pharmacy-c
- hhs.gov/sites/default/files/hhs-503a-peptide-enforcement-discretion-policy-appendix-b.pdf
- ema.europa.eu/en/medicines
Reddit threads read · 20
- r/Peptides
- r/Peptides
- r/Biohacking
- r/Peptides_for_Women
- r/BiohackingU
- r/Peptides
- r/PeptidePathways
- r/PeptideForum
- r/Peptidesource
- r/steroidify
- r/PeptideGuide
- r/NTNPerformance
- r/PeptidePathways
- r/NTNPerformance
- r/PeptideDiscussion
- r/Biohacking
- r/Biohacking
- r/suppgains
- r/BiohackingU
- r/Biohacking
6 further sources on commercial or non-primary hosts not listed.
Research checked 2026-11-13.