FOXO4-DRI

Read 1. No verified man aged 45–60 (n=0). Two specific firsthand reports: one described more pliable fibrotic nodules, better range of motion and less pain/inflammation (later stacked with SS-31, KLOW and MOTS-c), the other a severe sustained blood-pressure rise to about 203/103 after two injections, needing extra medication. Blood pressure is the most consequential signal in this tiny corpus.

Read 2. No man aged 45–60; the only clearly male user was in his late 30s and reported fatigue and two days of injection pain after 80 mg in a week, with no noticeable benefit. Nine users from 6 threads: mostly unclear (4) or no effect (2), plus 1 positive ("felt 15 years younger"), 1 mixed (5–11 lb weight loss with lethargy and headaches) and 1 negative. Commonest side effects: sore injection sites for 18 hours to several days, fatigue, headache, over very short 5–21-day cycles. Two limited or ended cycles because 100 mg protocols cost about $1,200.

Note 1. Only two verified firsthand reports were sufficiently specific. One positive course became stacked, limiting attribution.

Note 2. No men 45-60 (a 67-year-old did not state sex). r/BodyHackGuide and promotional guides were excluded. A third-party report about a 46-year-old long-COVID subject was not counted.

Each read counted people independently. Overlap between the two reads is estimated from shared threads and removed; counts are approximate. How we count.