C-terminal growth hormone peptide fragment; native-sequence fragment distinguished from the AOD-9604 analogue

Human growth hormone fragment 176–191

aka hGH(176–191) · HGH Fragment · HGH Frag 176–191 · Somatotropin (176–191)

Evidence grade
Grade D: Preclinical only
for fat loss (native-sequence hGH 176-191)
User score everyone · n = 19
US FDA Not approved checked 2026-11-13
WADA 2026 Prohibited (S2.2.3) at all times · checked 2026-11-13
EU No data · checked 2026-11-13

Goals: Fat loss Compare with another peptide →

User reports

approximate — combined from two independent Reddit reads

Men 45–60

0 men aged 45–60

No reports in this group yet.

All men

4 men

small sample · n = 4

Outcome positive 3 of 4 · mixed 1 of 4

Benefits fat loss 4 of 4 · energy 1 of 4 · muscle 1 of 4

Side effects none reported

Stopped 0 of 4 Used with other compounds 2 of 4

Everyone

19 people

  • Positive: 7 of 19 (37%)
  • Mixed: 5 of 19 (26%)
  • Negative: 1 of 19 (5%)
  • No effect: 2 of 19 (11%)
  • Unclear: 4 of 19 (21%)
Benefits reported of 19
Benefits reported (n = 19)
ItemReports
Fat loss11 of 19 (58%)
Endurance1 of 19 (5%)
Energy1 of 19 (5%)
Joints / tendons1 of 19 (5%)
Less appetite1 of 19 (5%)
Muscle1 of 19 (5%)
Sleep1 of 19 (5%)
Side effects reported of 19
Side effects reported (n = 19)
ItemReports
Other2 of 19 (11%)
Injection site1 of 19 (5%)
Vivid dreams1 of 19 (5%)
Why people stopped of 19
Why people stopped (n = 19)
ItemReports
Cost1 of 19 (5%)
Goal reached1 of 19 (5%)
Other1 of 19 (5%)

Stopped 3 of 19 (16%) Used with other compounds 7 of 19 (37%)

User reports are anecdata, not evidence: self-selected, unverified, often combined with other compounds.

In their words

  • “After 4 weeks I have seen a drop in inches around my waist”

  • “Frag 176-191 has done for me what I never thought possible.”

  • “In two weeks my arthritis was gone, my 3 surgery knee pain was gone.”

  • “I've used Frag before, it literally did nothing. Even had it tested to make sure it was legit.”

  • “Only benefit I have noticed is the quality of sleep ! I am sleeping the best I have ever had”

  • “Lost 7lbs in 3 weeks after upping my cals and slacking on diet, how much of that was fat and how much was water/glycogen”

Read summaries and method notes

Read 1. No man aged 45–60; the only aged man was 41 (all men only), who reported four weeks of daily fasted dosing, a smaller waist and a small weight drop while keeping muscle. A second user reported arthritis and post-surgical knee pain gone within two weeks; a third had just started a stack (unclear). No verified adverse effects.

Read 2. No man aged 45–60 (the only known-age user over 45 was a 48-year-old woman who gained weight on a frag/testosterone combination). All men (n=3): 2 positive, 1 mixed for fat loss and energy at 500–1,500 mcg daily, two with TRT or ephedrine alongside. Everyone (n=17, 10 threads): 6 positive, 5 mixed, mostly fat loss; side effects rare (nodules, intense dreams, unwanted weight gain). Two users noticed nothing at all. Typical use 3.5–12 weeks fasted before cardio.

Note 1. Very small corpus. The 41M report is below the 45-60 range. One user had only just started a multi-peptide stack and is coded unclear.

Note 2. No men 45-60; the only 48-year-old was female. One thread showed only a reply without the OP and was not counted. r/1UpGuides, sponsored r/amino_asylum and r/BodyHackGuide were excluded; AOD-9604 and plain HGH reports were filtered out.

Each read counted people independently. Overlap between the two reads is estimated from shared threads and removed; counts are approximate. How we count.

Summary

Native hGH(176–191) is a C-terminal growth hormone fragment, distinct in sequence from the modified AOD-9604 analogue. Human fat-loss efficacy and effects on glucose or insulin are not established for the native fragment. AOD-9604 failed in its obesity programme; grade D for the untested native sequence does not imply superior efficacy.

Safety

  • Human adverse-event rates and long-term safety for the native fragment are not established.
  • No validated human dose, half-life or contraindication list was found.
  • Absence of glucose or insulin effects has not been established in human trials of the native fragment.
  • AOD-9604 trial findings and FDA warnings are not direct evidence about a sequence-verified native-fragment product.

From labels, regulators and trials. No signal in small studies ≠ safe.

Evidence D fat loss (native-sequence hGH 176-191)

D stands. No human trial of the native-sequence fragment was found. It is sold as interchangeable with AOD-9604, whose obesity programme failed (F), so the page must not let D read as 'better than AOD-9604'.

Human trials · 0

No human trials found for the marketed use.

Dose ranges

Reported ranges from labels and studies, with context. Not a recommendation.

No data.

Editorial ratings EDITORIAL

Editors’ judgement, 0–5. Opinion, not data; separate from grade and user score.

  • Safety 4 out of 5
  • Sleep 2 out of 5
  • Recovery not rated —
  • Cognitive not rated —

Sources

  1. fda.gov/media/94155/download
  2. wada-ama.org/sites/default/files/2025-09/2026list_en_final_clean_september_2025.pdf?embed=
  3. ema.europa.eu/en/medicines
  4. pmc.ncbi.nlm.nih.gov/articles/PMC9249349/
  5. pubmed.ncbi.nlm.nih.gov/8358331/
  6. accessdata.fda.gov/scripts/cder/daf/
  7. clinicaltrials.gov/search?term=%22hGH%20176-191%22
  8. pubmed.ncbi.nlm.nih.gov/?term=%22somatotropin+%28176-191%29%22
  9. ema.europa.eu/en/search?search_api_fulltext=176-191
  10. precision.fda.gov/uniisearch/srs/unii/7up768ip4m
  11. pubmed.ncbi.nlm.nih.gov/11146367/
  12. fda.gov/media/183584/download
  13. fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-pres
  14. fda.gov/media/185642/download
  15. fda.gov/advisory-committees/advisory-committee-calendar/july-23-24-2026-meeting-pharmacy-c
  16. pubmed.ncbi.nlm.nih.gov/8358331/?format=pubmed
  17. pubmed.ncbi.nlm.nih.gov/11146367/?format=pubmed

Reddit threads read · 13

6 further sources on commercial or non-primary hosts not listed.

Research checked 2026-11-13.