MOTS-c

Read 1. Two qualifying male self-reports were identified: a 50-year-old described improved workout energy, while a 52-year-old noticed fewer naps but explicitly questioned whether MOTS-c was responsible. Both were using multiple compounds, which prevents reliable attribution. Among all 15 coded users, energy and endurance improvements appeared repeatedly, but fatigue, insomnia, injection-site reactions, and an elevated heart rate were also reported. The reported onset ranged from immediate exercise effects to changes over several weeks; some users reported no meaningful effect even after prolonged use. Twelve reports involved stacks, making the sample particularly weak for estimating MOTS-c's independent effects.

Read 2. No man aged 45–60; one man stated age (25M, no effect after a week). Fourteen users: 4 positive, 4 mixed, 3 negative, 2 no effect, 1 unclear — energy, endurance, bowel regularity, fat loss, especially with SS-31, NAD+ or 5-amino-1MQ. Side effects were prominent: paradoxical daytime fatigue (3), resting heart rate jumping from 50–60 to 80–90 bpm (3, two stacked with retatrutide), irritability, chest tightness, near-fainting at the gym. Six of 14 stacked.

Note 1. The 52M report is coded unclear despite mentioning improved energy because the author expressly questioned attribution. A 45-year-old author's sex was unstated and therefore that report appears only in everyone. Results are highly confounded by SS-31, NAD+, retatrutide, and other peptide stacks. Moderated-out original posts, hearsay, vendor promotions, and plans to try MOTS-c were not counted. Only selected verifiable reports were coded.

Note 2. One r/BodyHackGuide thread was excluded. Frequent co-use with retatrutide or SS-31 confounds heart-rate and energy attribution.

Each read counted people independently. Overlap between the two reads is estimated from shared threads and removed; counts are approximate. How we count.